Cognitive neuroscience: Pause for thought

Introduction: the cognitive neuroscience of thought.

Human thought has been a puzzling subject among philosophers for the major part of our recorded history, most famously encapsulated in Descartes' Cogito ergo sum (I think therefore I am). Although our knowledge of thought and its benefits has come a long way since Descartes, it is only in recent times that empirical investigations into theneuroscientific bases of thought and cognition have been...

γ-TuRC gives microtubules pause for thought

A protein complex better known for its role in microtubule nucleation at the centrosome is also a stabilizing factor that controls cytoskeletal ␥-Tubulin and its partners in the ␥-tubulin ring complex (␥-TuRC) initiate the growth of new microtubules. This is particularly important during mitosis—cells missing ␥-TuRC subunits either fail to divide or go through the process slowly. Little is know...

Thought disorder in schizophrenia: cognitive and neuroscience approaches.

Research with schizophrenics is reviewed in the areas of the startle reflex, subject-initiated evoked potentials, and two-stimulus evoked potentials. A hypothesis of an early (pre-100 ms) information-processing deficit is posited and further refined by results presented from brain evoked potentials during a backward-masking experiment. The implications of these findings for the speech component...

Poised RNA Polymerase II Gives Pause for Thought

Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

Cognitive neuroscience.